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Labeling a bacterial cell 'jacket': Team invents scientific method to track cells implicated in immune diseases

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The immune system research team: From left Prof. Catherine Grimes, doctoral students Hai Liang and Ching-Wen (Sandy) Hou, Jeff Caplan, director of the Bio-Imaging Center, doctoral student Kristen DeMeester and Prof. Michelle Parent. Credit: Evan Krape/ University of Delaware

You have three to five pounds of bacteria living in and on your body right now. That's some 38 trillion bacteria, researchers estimate. Your immune system has to manage all of them, sorting out the good from the bad bugs.

"We have an amazing immune system to keep that all in check, and then to deal with pathogenic ," says Catherine Leimkuhler Grimes, assistant professor of chemistry and biochemistry at the University of Delaware. "It's fantastic when the system works, but also horrific when it doesn't."

When a beneficial bacterium is mistakenly identified as a harmful one, the immune system's attack can trigger such as asthma, Crohn's disease and other disorders. Why this misidentification occurs is a mystery, but Grimes and her research team at the University of Delaware have invented a promising new method to literally help illuminate what happens. The advance is published in Nature Communications.

Read more at:

https://phys.org/news/2017-05-bacterial-cell-jacket-team-scientific.html#jCp
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