Chances are your body's immune system is
saving your neck again right now, working quietly in the background to
defeat whatever viruses, bacteria, fungi or other enemies have gotten
into you.
However, the system needs to protect you while a trillion good
bacteria reside in or on your body. It's an important balance to
maintain.
Catherine Leimkuhler Grimes, assistant professor of chemistry and biochemistry
at the University of Delaware, has been studying the immune system for
several years, especially its capacity for identifying enemy forces. How
do cells distinguish between harmful bacteria and helpful bacteria?
The work is critical for global health, with treatment-resistant
bacteria a growing concern and long-term immune system problems such as
Crohn's disease, lupus, and irritable bowel syndrome increasingly
common.
Grimes' research requires sophisticated analysis of proteins and
their role in identifying bacterial threats. Specifically, she is trying
to learn how a class of unstable proteins is able to sense the presence
of bacteria. Her laboratory is investigating how the immune systems of
humans and yeast are triggered when they encounter certain fragments of
bacterial cell walls.
Grimes finds it fascinating that the yeasts that live inside the
human body have developed “hands,” or receptors, to grab the fragments
of bacterial cell wall that resemble the human receptors.
Now the National Science Foundation (NSF) has recognized the promise
of Grimes' research with a five-year, $750,000 Faculty Early Career
Development Award, one of the most prestigious such grants available to
young scientists.
Grimes and the student researchers in her lab are now working to
define the differences between the human and yeast systems. Using new
biochemical techniques, her team strives to unveil the recognition
mechanisms.
“I feel extremely lucky to work with such a dynamic group of
students," Grimes said. "They are as committed to these problems as I
am. We truly work as a team.”
Her team collaborates with a number of chemists at UD, including the
laboratories of Brian J. Bahnson and Tatyana Polenova to gain structural
information, as well as a yeast geneticist at Villanova University,
Dennis Wykof.