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University of Delaware201 AP Biopharm, Star CampusNewark, DE 19716<div class="ExternalClass7E93754A02324C31BE61FF4D5C2E887B"><p>​<strong><strong>B.S. - Villanova University (2001, Chemistry); M.S. - Princeton University (2003, Chemistry); Ph.D. - Harvard University (2007, Chemistry and Chemical Biology); Cancer Research Institute Postdoctoral Fellow at Harvard University and Massachusetts General Hospital  (2007 - 2011, Molecular and Cellular Biology)</strong></strong></p></div><div class="ExternalClass5417AA864E284E858E8C736C0E826FF4"><p>The Grimes Research program focuses on the development and chemical synthesis of small molecule carbohydrate probes that mimic intermediates of bacterial cell wall biosynthesis and bacterial-host immune recognition. The Lab’s work encompassed a mixture of carbohydrate chemistry, molecular biology and biochemistry to answer questions regarding how the human body senses and responds to the presence of bacteria. </p><p>Dr. Leimkuhler Grimes is nationally recognized as a young leader in the field of chemical biology, as she has received numerous awards including a Pew Biomedical Scholars Award, a Cottrell Scholar, and an Alfred P. Sloan Research Fellowship. She received the American Chemical Society’s Infectious Disease Young Investigator Award and the Dryefus Teacher Scholar Award. She is the co-director of a NIH funded graduate program at the interface of chemistry and biology and the faculty mentor to a dynamic group of undergraduate STEM majors, “The Scientistas”.<br></p><p>Short <a href="https://www.youtube.com/watch?v=xqHml-Mq9Bk" target="_blank">Video</a> of Catherine Talking about the Lab’s work (thanks to the Dreyfus Foundation).<br></p></div><div class="ExternalClassFDCCFD274EB240D781ADB3504F4940A0"><ul><li>Lazor KM, Zhou J, DeMeester KE, D'Ambrosio EA, Grimes CL.* “Synthesis and Application of Methyl N,O-Hydroxylamine Muramyl Peptides”. Chembiochem. (2019) 20, 1269-1375. </li><li>DeMeester, KE, Liang, H, Jensen, M Jones, Z, D'Ambrosio, E, Scinto, S, Zhou, J, Grimes, CL.*,  “Synthesis of functionalized N-acetyl muramic acids to probe bacterial cell wall recycling and biosynthesis.” J. Am. Chem. Soc. (2018), 140, 9458-9465. </li><li>Schaefer AK, Wastyk HC, Mohanan V, Hou CW, Lauro ML, Melnyk JE, Burch JM, Grimes CL*. “Crohn's Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70” Biochemistry (2017), 56, 4445-4448.</li><li>Schaefer AK, Melnyk JE, Baksh MM, Lazor KM, Finn MG, Grimes CL*. “Membrane Association Dictates Ligand Specificity for the Innate Immune Receptor NOD2” ACS Chem Biol. (2017) 12, 2216-2224.<br></li><li>Liang H, DeMeester KE, Hou CW, Parent MA, Caplan JL, Grimes CL*. Metabolic labeling of the carbohydrate core in bacterial peptidoglycan and its applications. Nat Commun. (2017) 8, 15015.</li><li>Melnyk, J.E., Mohanan, V., Schaefer, A.K., Hou, C-H., Grimes, C.L. *, “Peptidoglycan Modifications Tune the Stability and Function of the Innate Immune Receptor Nod2”, J Am Chem Soc, (2015) 137, 6987.</li><li>Mohanan, V., Grimes, C.L.*, “The Molecular Chaperone HSP70 binds to and stabilizes NOD2, an important protein in Crohn’s Disease”, J. Biol. Chem, (2014), 289, 18987. </li></ul></div>Current ResearchRepresentative publicationscgrimes@UDel.EduLeimkuhler Grimes, Catherine E.(302) 831-2985<img alt="" src="/Images%20Bios/Grimes,%20Catherine.jpg" width="360" style="BORDER:0px solid;" />Professorhttp://sites.udel.edu/grimesgroup/

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