Skip to Main Content
Sign In
Visit Apply Give
Toggle Navigation

Open the Navigation Management window, which can be used to view the full current branch of the menu tree, and edit it.

CONNECT
  • Facebook
  • EMail

Bio Full List - Searchable

Image Picker for Section 0

 For Google

  • Catherine L. Grimes, Professor

    Professor
    University of Delaware
    140 Brown Lab
    Newark, DE 19716
    (302) 831-2985
    http://sites.udel.edu/grimesgroup/

    Biography

    B.S. - Villanova University (2001, Chemistry); M.S. - Princeton University (2003, Chemistry); Ph.D. - Harvard University (2007, Chemistry and Chemical Biology); Cancer Research Institute Postdoctoral Fellow at Harvard University and Massachusetts General Hospital  (2007 - 2011, Molecular and Cellular Biology)

    Current Research

    The Grimes Research program focuses on the development and chemical synthesis of small molecule carbohydrate probes that mimic intermediates of bacterial cell wall biosynthesis and bacterial-host immune recognition. The Lab’s work encompassed a mixture of carbohydrate chemistry, molecular biology and biochemistry to answer questions regarding how the human body senses and responds to the presence of bacteria.

    Dr. Leimkuhler Grimes is nationally recognized as a young leader in the field of chemical biology, as she has received numerous awards including a Pew Biomedical Scholars Award, a Cottrell Scholar, and an Alfred P. Sloan Research Fellowship. She received the American Chemical Society’s Infectious Disease Young Investigator Award and the Dryefus Teacher Scholar Award. She is the co-director of a NIH funded graduate program at the interface of chemistry and biology and the faculty mentor to a dynamic group of undergraduate STEM majors, “The Scientistas”.

    Short Video of Catherine Talking about the Lab’s work (thanks to the Dreyfus Foundation):  https://www.youtube.com/watch?v=xqHml-Mq9Bk

    Representative publications

    • Lazor KM, Zhou J, DeMeester KE, D'Ambrosio EA, Grimes CL.* “Synthesis and Application of Methyl N,O-Hydroxylamine Muramyl Peptides”. Chembiochem. (2019) 20, 1269-1375.
    • DeMeester, KE, Liang, H, Jensen, M Jones, Z, D'Ambrosio, E, Scinto, S, Zhou, J, Grimes, CL.*,  “Synthesis of functionalized N-acetyl muramic acids to probe bacterial cell wall recycling and biosynthesis.” J. Am. Chem. Soc. (2018), 140, 9458-9465.
    • Schaefer AK, Wastyk HC, Mohanan V, Hou CW, Lauro ML, Melnyk JE, Burch JM, Grimes CL*. “Crohn's Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70” Biochemistry (2017), 56, 4445-4448.
    • Schaefer AK, Melnyk JE, Baksh MM, Lazor KM, Finn MG, Grimes CL*. “Membrane Association Dictates Ligand Specificity for the Innate Immune Receptor NOD2” ACS Chem Biol. (2017) 12, 2216-2224.
    • Liang H, DeMeester KE, Hou CW, Parent MA, Caplan JL, Grimes CL*. Metabolic labeling of the carbohydrate core in bacterial peptidoglycan and its applications. Nat Commun. (2017) 8, 15015.
    • Melnyk, J.E., Mohanan, V., Schaefer, A.K., Hou, C-H., Grimes, C.L. *, “Peptidoglycan Modifications Tune the Stability and Function of the Innate Immune Receptor Nod2”, J Am Chem Soc, (2015) 137, 6987.
    • Mohanan, V., Grimes, C.L.*, “The Molecular Chaperone HSP70 binds to and stabilizes NOD2, an important protein in Crohn’s Disease”, J. Biol. Chem, (2014), 289, 18987. 

 

 

Page Settings and MetaData:
(Not Shown on the Page)
Page Settings
Bio2
No
MetaData for Search Engine Optimization
University of Delaware
<a target="_blank" href="/Lists/Bios/AllItems.aspx" class="ms-promotedActionButton"> <span style="font-size:16px;margin-right:5px;position:relative;top:2px;" class="fa fa-pencil-square-o"></span><span class="ms-promotedActionButton-text">EDIT LIST</span> </a> <a target="_blank" href="/cas-it/utility/ir-bio" class="ms-promotedActionButton"> <span style="font-size:16px;margin-right:5px;position:relative;top:2px;" class="fa fa-crop"></span><span class="ms-promotedActionButton-text">CROP IMAGES</span> </a> <a target="_blank" href="/Images%20Bios/Forms/Thumbnails.aspx" class="ms-promotedActionButton"> <span style="font-size:16px;margin-right:5px;position:relative;top:2px;" class="fa fa-camera"></span><span class="ms-promotedActionButton-text">UPLOAD IMAGES</span> </a> <a target="_blank" href="/Documents Bios CVs/Forms/AllItems.aspx" class="ms-promotedActionButton"> <span style="font-size:16px;margin-right:5px;position:relative;top:2px;" class="fa fa-file-text"></span><span class="ms-promotedActionButton-text">UPLOAD CV'S</span> </a> WebPartEditorsOnly hideHeader
  • Chemistry and Biochemistry
  • 102 Brown Laboratory
  • University of Delaware
  • Newark, DE 19716, USA
  • Phone: 302-831-1247
  • chemistry@udel.edu