Karl S. Booksh, Professor
University of Delaware
002 Lammot DuPont Laboratory
Newark, DE 19716
B.S., 1990, University of Alaska - Fairbanks; Ph.D., 1994, University of Washington - Seattle
Our research interest is the development of in-situ chemical sensors for environmental, biomedical, and industrial process monitoring. Specifically, the research group has been concentrating on advancement of fiber optic surface plasmon resonance (SPR) Raman, and fluorescence sensors. In developing these sensors we meld instrumental design with advanced data analysis (Chemometrics) methods to achieve optimal instrumental performance. This research is driven by the realization that many measurement challenges – particularly problems involving analyte selectivity and sensitivity – are not best addressed by solely applying chemistry or physics solutions. These ‘physical’ solutions are often time, labor, and capital expensive. Instead, instrumental selectivity and sensitivity (and robustness) can often be enhanced by incorporating mathematical and statistical analysis of the collected data into the instrumental design.
With the SPR sensors we have two goals.
We are investigating the utility of the fiber optic sensors for in-vitro and in-vivo determination of proteins indicative of disease diagnoses, wound healing, and proteomic screening. We are also combining the SPR sensors with molecular imprinted polymers to detect small molecules with applications in homeland defense and monitoring air quality.
The fiber optic Raman and fluorescence sensors are targeted at environmental process monitoring. The ultimate goal is deployment of spectroscopic systems to monitor the chemistry of deep sea hydrothermal vent systems. However, the fluorescence sensors are also being used for tracking the distribution and fate of pesticides and polycyclic aromatic hydrocarbons in the environment. The Raman sensor is being employed for determining the bioavailability of nutrients in the environment and to study chemical reactions in hydrothermal reactors.
- M. K. Boysworth, S. Banerji, D. M. Wilson, and K. S. Booksh “Generalization of multivariate optical computations as a method for improving the speed and precision of spectroscopic analyses,” Journal Of Chemometrics, (2008) 22(5-6), 355 – 365.
- J. F. Masson, T. M. Battaglia, P. Khairallah, S. Beaudoin, and K. S. Booksh “Quantitative measurement of cardiac markers in undiluted serum,” Analytical Chemistry, (2007) 79(2), 612 – 619.
- J. A. Cramer and K. S. Booksh “Chaos theory in chemistry and chemometrics: a review,” Journal of Chemometrics, (2006) 20(11-12), 447 – 454.
- D. J. Gentleman and K. S. Booksh “Determining salinity using a multimode fiber optic surface plasmon resonance dip-probe,” Talanta, (2006) 68(3), 504 – 515.
- M. L. Nahorniak and K. S. Booksh “Excitation-emission matrix fluorescence spectroscopy in conjunction with multiway analysis for PAH detection in complex matrices,” Analyst, (2006) 131(12), 1308 – 1315.
- J. F. Masson, T. M. Battaglia, J. Cramer, S. Beaudoin, M. Sierks, and K. S. Booksh “Reduction of nonspecific protein binding on surface plasmon resonance biosensors,” Analytical And Bioanalytical Chemistry, (2006) 386(7-8), 1951 – 1959.
- T. M. Battaglia, J. F. Masson, M. R. Sierks, S. P. Beaudoin, J. Rogers, K. N. Foster, G. A. Holloway and K. S. Booksh “Quantification of cytokines involved in wound healing using surface plasmon resonance,” Analytical Chemistry, (2005) 77, 7016 – 7023.
- Y. C. Kim, S. Banerji, J. F. Masson, W. Peng, K. S. Booksh “Fiber-optic surface plasmon resonance for vapor phase analyses,” Analyst, (2005) 130, 838 – 843.
- Y. C. Kim, J. A. Jordan, M. L. Nahorniak, K. S. Booksh “Photocatalytic degradation-excitation-emission matrix fluorescence for increasing the selectivity of polycyclic aromatic hydrocarbon analyses,” Analytical Chemistry, (2005) 77, 7679 – 7686.
- J. F. Masson, M. Barnhart, T. M. Battaglia, G. E. Morris, R. A. Nieman, P. J. Young, C. L. Lorson and K. S. Booksh “Monitoring of recombinant survival motor neuron protein using fiber-optic surface plasmon resonance,” Analyst, (2004) 129, 855 – 859.
- T. M. Battaglia, E. E. Dunn, M. D. Lilley, J. Holloway, B. K. Dable, B. J. Marquardt, K. S. Booksh “Development of an in situ fiber optic Raman system to monitor hydrothermal vents,” Analyst, (2004) 129, 602 – 606.
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